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Intravenous Treatment of Hypokalemic Periodic Paralysis
Robert C. Griggs, MD;
Jerome Resnick, MD;
W. King Engel, MD
Arch Neurol. 1983;40(9):539-540.
Abstract
• Acute attacks of weakness in patients with hypokalemic periodic paralysis can usually be treated with oral potassium preparations. Occasional patients, however, require intravenous (IV) potassium administration. We studied a patient with hypokalemic periodic paralysis to determine the effect of using 5% glucose as a diluent for potassium administration during acute attacks of weakness. Administration of IV potassium chloride in 5% glucose (50 mEq/L) was associated with a worsening of strength and no rise in potassium level. Intravenous potassium in 5% mannitol was associated with a rise in potassium and improvement in strength. This study confirms the hazard of using glucose-containing solutions for correction of hypokalemia.
Author Affiliations
From the Department of Neurology, University of Rochester (NY) (Dr Griggs); the Department of Neurology, Stamford (Conn) Hospital (Dr Resnick); and the Departments of Neurology and Pathology, Center for Neuromuscular Diseases, University of Southern California, Los Angeles (Dr Engel).
Footnotes
Accepted for publication Nov 29, 1982.
Reprint requests to Department of Neurology, Box 673, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642 (Dr Griggs).
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