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Cognition, Ventricular Size, and Leuko-Araiosis

Judith Aharon-Peretz, MD; Jeffrey L. Cummings, MD; Mary Ann Hill, PhD

Arch Neurol. 1988;45(7):719-721.

Abstract
• Multi-infarct dementia (MID) and dementia of the Alzheimer type (DAT) were compared with regard to ventricular size and leuko-araiosis (LA) on computed tomographic scans. Ninety-seven percent of patients with MID and 55.5% of patients with DAT had evidence of LA. The severity of LA was scored with a 0 through 4 rating system, and LA was found to be significantly more severe in patients with MID than in patients with DAT. Patients with MID, but not those with DAT, exhibited correlations between enlargement of the third and lateral ventricles and severity of cognitive impairment.

Author Affiliations
From the Neurobehavior Unit (Drs Aharon-Peretz and Cummings), and the Research and Development Service (Dr Hill), West Los Angeles Veterans Administration Medical Center (Brentwood Division); and the Departments of Neurology (Drs Aharon-Peretz and Cummings) and Psychiatry and Biobehavioral Sciences (Dr Cummings), UCLA School of Medicine.

Footnotes
Accepted for publication Feb 22, 1988.

Reprint requests to Neurobehavior Unit, Medical Service (691/Blll), West Los Angeles Veterans Administration Medical Center (Brentwood Division), 11301 Wilshire Blvd, Los Angeles, CA 90073 (Dr Cummings).

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