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COMMENTS AND OPINIONS
Mediterranean Dietary Pattern, Mild Cognitive Impairment, and Progression to Dementia—Reply
Nikolaos Scarmeas, MD;
Yaakov Stern, PhD;
Jennifer J. Manly, PhD;
Nicole Schupf, PhD;
Jose A. Luchsinger, MD;
Richard Mayeux, MD
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In reply
In their letter, Solfrizzi and colleagues raise concerns similar to those they have previously expressed in response to our work on this topic. They suggest the possible use of the alternate cut point method applied by Mitrou et al1 (ie, rather than using the 50th percentile, assigning points to intakes  25th percentile or <75th percentile for "beneficial" or "detrimental" components of the MeDi calculation) for a sensitivity analysis. Unfortunately, using this method is not practical in our study owing to power limitations. More specifically, in applying this method in the cognitively normal to incident MCI analyses (N = 1393), a MeDi score of 6 would be assigned to 23 subjects (1.7%), a score of 7 to 9 subjects (0.6%), a score of 8 to 1 subject (0.1%), and a score . . . [Full Text of this Article] AUTHOR INFORMATION
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