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Parkinson Disease: Extranigral, Multisystem, and -Synuclein "Plus"

Michail E. Kalaitzakis, PhD; Manuel B. Graeber, MD, PhD, FRCPath; Stephen M. Gentleman, PhD; Ronald K. B. Pearce, MD, PhD, FRCPC, FRCP

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

The review by Lim et al¹ reminds its audience that Parkinson disease (PD) is a multisystem disorder. While the review addresses the multiplicity of derangements in the PD brain with resultant clinical manifestations and also alludes to pathologic findings other than -synuclein deposition, certain further facts need to be mentioned in the context of "extranigral" pathologic findings.

Lim and colleagues state that "the Braak staging scheme . . . has been largely confirmed by other investigators . . . "¹ and thereby cite an article by Dickson et al.² In fact, the study by Dickson and colleagues did not seek explicitly to address the staging of -synuclein deposition. Rather, it demonstrated that in incidental Lewy body disease cases, -synuclein pathologic findings were observed simultaneously in multiple regions of both the central and peripheral nervous systems, implying . . . [Full Text of this Article]

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Overview of the Extranigral Aspects of Parkinson Disease
Shen-Yang Lim, Susan H. Fox, and Anthony E. Lang
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Parkinson Disease: Extranigral, Multisystem, and -Synuclein "Plus"—Reply
Shen-Yang Lim, Susan H. Fox, and Anthony E. Lang
Arch Neurol. 2009;66(7):915-916.
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